Astrocytes in schizophrenia
نویسندگان
چکیده
منابع مشابه
[Role of astrocytes in alterations of glutamatergic neurotransmission in schizophrenia].
The glutamatergic hypothesis of schizophrenia based on the hypofunction of the N-methyl-D-aspartate-type glutamate receptors (NMDA-R) is one of the most widely implicated hypothesis that explains the origin of positive and negative symptoms of illness as well as cognitive deficits. The author considered a neuromorphological aspect of this hypothesis related to the glial astrocytes function. The...
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OBJECTIVE Previously the ultrastructural alterations of astrocytes have been reported in schizophrenia. Reduced dendritic arborization of the neurons in layer 5 of the prefrontal cortex has been found in schizophrenia. Authors hypothesized that the abnormalities in perineuronal astrocytes (PA) might contribute to these neuronal changes. It was aimed to study the ultrastructure of PA in the pref...
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Introduction: Previous studies have suggested that the cerebellum is a primary site of motor learning. The cerebellar cortex has a particular glial architecture with large astroglial cells. In addition, more recent works have revealed that astrocytes play a more active role in neuronal activity. The aim of this study was to evaluate the number of astrocytes in the molecular layer of rat's cere...
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Schizophrenia is a severe psychiatric illness with a lifetime prevalence of ˜1% that imposes a huge toll on patients, their families and public health services worldwide. Delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior and negative symptoms constitute the core symptoms of schizophrenia. Although the neurotransmitter dopamine plays a prominent role in t...
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Obesity and its associated complications impose a huge burden to our society, and constitute a major cause of death. However, the molecular and circuits mechanisms underlying this disorder are largely unknown. At its core, obesity results from an imbalance between energy intake and energy expenditure. Most work has focused on neuronal control of energy homeostasis, while effective treatments ar...
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ژورنال
عنوان ژورنال: Brain and Neuroscience Advances
سال: 2021
ISSN: 2398-2128,2398-2128
DOI: 10.1177/23982128211009148